Roche Postdoctoral Fellowship (RPF) Researcher visualizing ultrastructures related to Alzheimer’s Disease with Electron Microscopy
Roche
Bâle
CDI
Temps-plein
Il y a 1 mois
Roche fosters diversity, equity and inclusion, representing the communities we serve. When dealing with healthcare on a global scale, diversity is an essential ingredient to success. We believe that inclusion is key to understanding people’s varied healthcare needs. Together, we embrace individuality and share a passion for exceptional care. Join Roche, where every voice matters.The PositionThe Roche Postdoctoral Fellowship (RPF) Program has the ambition to build and maintain the Scientific Leadership of the future and to provide leading Roche scientists with the opportunity to collaborate with talented postdoctoral researchers, and leading academic research groups, from around the world.One of the key aims is to advance basic science and technologies that will be published in top-rated, peer-reviewed scientific journals if necessary preceded by priority patent applications.We are looking for a talented and enthusiastic postdoctoral scientist to join our electron microscopy team in pRED at Roche in Basel, Switzerland. The mission is dedicated to the visualization of human brain pathology, as well as the isolation and representation of pathologic inclusions that underlie Alzheimer’s Disease. This mission embeds in a highly collaborative industrial research environment and will bridge our discovery efforts with disease-relevant insights gathered with methods and preparative tricks established at the EPFL in Lausanne, Switzerland. It is a project at the interface between outstanding groups at EPFL and Roche, with the work location split between Basel and Lausanne.You will join a vibrant multicultural team of scientists, associates, postdocs and students working towards innovative approaches for drug discovery in the nervous system.Who you areYou have studied Biochemistry, Neurobiology, Neuroscience, Life Science, Medical Biology, Biophysics/Physics or Nanosciences and completed your PhD not longer than 4 years ago.Your PhD thesis focused on high-resolution cryogenic Transmission Electron Microscopy and included the structure determination of helical filaments, as well as their inspection in cryogenically preserved human brains.You know how to fixate and preserve brain tissue for analysis with electron microscopy with resin embedding techniques, as well as cryogenic preservation methods.You have hands-on experience with multiscale imaging techniques, and you have employed immunohistochemistry to find relevant target structures in cryopreserved tissue for structure determination with Transmission Electron Microscopy.You have a fundamental understanding of the human brain anatomy, as well as the microstructure of neurons and cells in tissue.Correlative Light Electron Microscopy, CEMOVIS, cryo-FIB-SEM, Electron Tomography are routine methods for you.You enjoy exploring and applying novel technologies and preparation techniques to extract and isolate structures from tissue (laser micro capturing and related methods).You are well-trained on and routinely employ digital analysis tools for image analysis, including the 3D reconstruction of helical protein structures.You are someone who is driven by the desire to find therapeutics for some of the most complicated and devastating disorders. You enjoy teamwork, diligence and efficiency. Working in a multicultural environment motivates you.You have been actively engaged in scientific research continuously since your PhD and ready to start an RPF postdoctoral activity no later than 4 years after PhD completion.The duration of the RPF project is initially set for two years, with the possibility of extension for a third year. This position is sponsored by the Roche Postdoctoral Fellowship Program. The collaborative research project will be conducted at both Roche Basel sites and at EPFL in Lausanne.When does it start?The planned start date of this fellowship is October 2024. Please clearly indicate your preferred starting date on your motivation letter.All applicants need to include a CV, motivation letter, a publication list and, if available, your PhD certificate.More information about the RPF Program:Our commitmentRoche commits to recognizing talent and aptitude. We prioritize encouraging and supporting our employees on their personal journeys by providing a safe, creative space to help them reflect, make decisions, and grow in their career.We are confident that we find the most innovative solutions by gaining different perspectives, asking and answering hard questions, and challenging the status quo. in a serious yet enthusiastic way; we are devoted to building a team that represents a range of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.Who we areAt Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. .Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.Roche is an Equal Opportunity Employer.
